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28

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1224	Cefuroxime sodium Anaptivan,头孢呋辛钠,Cefuroxime sodium salt,Biociclin	Antibacterial; Antibiotic	Microbiology/Virology
	Cefuroxime sodium (Cefuroxime sodium salt) 是一种具有口服活性的头孢菌素抗生素，增加了对 β-内酰胺酶的稳定性。
T26007	Pyrrofolic acid
	Pyrrofolic acid shows high anti-folate biological activity for S. faecalis.
T38021	Obafluorin
	Obafluorin is a β-lactone antibiotic that has been found in P. fluorescens.1 It is active against S. aureus, S. faecalis, K. pneumoniae, and P. vulgaris (MIC = 125 μg/ml for all). \|1. Pu, Y., Lowe, C., Sailer, M., et al. Synthesis, stability, and antimicrobial activity of (+)-obafluorin and related β-lactone antibiotics. J. Org. Chem. 59(13), 3642-3655 (1994).
T38334	Corynecin III
	Corynecin III is a chloramphenicol-like antibiotic originally isolated from Corynebacterium. It inhibits the growth of Gram-positive and Gram-negative bacteria, including S. faecalis, S. aureus, B. subtilis, E. coli, P. aeruginosa, P. vulgaris, S. sonnei, S. typhosa, and K. pneumoniae (MICs = 2.6-83 μg/ml).
T63252	Antibacterial agent 113
	Antibacterial agent 113 是有效的抗菌剂 (antibacterial)，对P.aeruginosa、S.mutans、B.subtilis、E.coli、E.faecalis、S.typhimuriumand 和S.aureus microorganisms 表现出抗菌作用，MIC 值均为 15625 μM。
T13149	Thiocillin I	Antibacterial	Microbiology/Virology
	Thiocillin I is a thiopeptide antibiotic and has in vitro antibacterial activity against Gram-positive bacterial strains(MIC of Thiocillin I against S. aureus 1974149, E. faecalis 1674621, B. subtilis ATCC 6633 and S. pyogenes 1744264 are 2 μg/mL, 0.5 μg/mL, 4 μg/mL and 0.5 μg/mL, respectively).
T83022	Antiproliferative agent-33
	Antiproliferative agent-33 (Compound 2g) 为抗增殖、抗真菌及抗菌化合物，可抑制MDA-MB-231细胞增殖（IC50为16.38 μM），并对革兰氏阴性菌具有生长抑制作用，S. faecalis的MIC值达到8 μg/mL。
T80371	Distinctin
	Distinctin是一种源自青蛙皮肤的抗菌肽，具有针对E. faecalis, P. aeruginosa, S. aureus和E. coli的抗菌活性，其最小抑菌浓度(MIC)分别为14.5 μM，28.0 μM，28.0 μM和14.5 μM。
T38321	A-39183A
	A-39183A is an active component of the A-39183 antibiotic complex produced by aerobic fermentation of Streptomyces NRRL 12049. It has activity against penicillin-resistant S. aureus 3055 and S. faecalis X66 (MICs = 32 and 32 μg/ml, respectively) and a variety of Gram-positive and Gram-negative anaerobic bacteria (MICs = 16-128 μg/ml) in an agar dilution assay.
T38314	Parvodicin Complex
	Parvodicin complex is a mixture of closely related lipophilic glycopeptides originally isolated from A. parvosata. The parvodicin complex has activity against Gram-positive bacteria (MICs = 0.8-12.5 μg/ml) including methicillin-resistant strains of S. aureus (MRSA), S. hemolyticus, and E. faecalis (MICs = 0.1-25 μg/ml). Glycopeptide antibiotics act by preventing cell wall synthesis by binding and sequestering a cell wall precursor with a D-alanine-containing peptide.
T37254	Rugulotrosin A
	Rugulotrosin A is an antibiotic originally isolated from Penicillium. It is active against the Gram-positive bacteria E. faecalis, B. cereus, B. subtilis, and S. aureus with 99% lethal dose (LD99) values of 1.6, 3.1, 5.5, and 200 μg/ml, respectively. Rugulotrosin A is inactive against Gram-negative bacteria.
T37039	Betulinic Aldehyde oxime
	Betulinic aldehyde oxime is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin .1It is active againstE. aerogenes,E. coli,E. faecalis,P. aeruginosa,S. aureus, andC. albicans, as well asL. donovaniamastigotes, when used at a concentration of 50 μM.1,2Betulinic aldehyde oxime (50 μM) is cytotoxic to Huh7 hepatocellular carcinoma cells.2
T80376	GP-2B
	GP-2B是一种具有针对革兰氏阳性菌株抗菌活性的抗菌肽，其最小抑菌浓度(MIC)针对金黄色葡萄球菌和粪肠球菌为8-128μg/mL。
T37286	1-Undecanoyl-rac-glycerol
	1-Undecanoyl-rac-glycerol is a monoacylglycerol that contains undecanoic acid at the sn-1 position. It completely inhibits the growth of the bacteria B. cereus, B. subtilis, M. luteus, E. faecalis, and S. aureus when used at concentrations ranging from 250 to 1,500 mg/L.1 1-Undecanoyl-rac-glycerol (0.1 and 0.3 mg/ml) also has antifungal activity against K. marxianus, S. cerevisiae, and C. maltosa.2
T38167	BE-24566B
	BE-24566B is a polyketide fungal metabolite originally isolated fromS. violaceusniger.1It is active againstB. subtilis,B. cereus,S. aureus,M. luteus,E. faecalis, andS. thermophilus(MICs = 1.56, 1.56, 1.56, 1.56, 3.13, and 3.13 μg/ml, respectively). BE-24566B is an endothelin (ET) receptor antagonist (IC50s = 11 and 3.9 μM for ETAand ETBreceptors, respectively).2 1.Kojiri, K., Nakajima, S., Fuse, A., et al.BE-24566B, a new antibiotic produced by Streptomyces violaceusnigerJ. Antibiot. (Tokyo)48(1...
T36181	Quinaldopeptin
	Quinaldopeptin is a quinomycin antibiotic. It is active against a variety of bacteria, including S. pyogenes, S. aureus, C. perfringens, S. faecalis, E. coli, and K. pneumoniae (MICs = 0.2, 0.4, 0.8, 1.6, 3.1 and 6.3 μg/ml, respectively). It is cytotoxic to B16/F10 and Moser cells (IC50s = 0.0008 and 0.04 μg/ml, respectively) and increases survival in a P388 leukemia mouse model. Quinaldopeptin is a bis-intercalator depsipeptide (NPBID) that binds to and intercalates into DNA (Kd = 32 nM).
T80378	Tilapia piscidin 3
	Tilapia piscidin 3 是具抗菌谱广的肽类化合物，有效对抗多种革兰氏阳性菌与阴性菌，其对 V. vulnificus 204、V. alginolyticus、S. agalactiae 819、E. faecalis BCRC 10066、S. agalactiae BCRC 10787 的最小抑菌浓度 (MIC) 分别为 2.44、2.44、9.78、19.55、0.61 μg/mL。同時，Tilapia piscidin 3 对鱼红细胞显示出溶血性。
T64197	Antibacterial agent 112
	Antibacterial agent 112 (compound 2) 是一种有效的抗菌剂 (antibacterial)。Antibacterial agent 112 对 P.aeruginosa (MIC: 625 μM)、S.mutans (MIC: 625 μM)、B.subtilis (MIC: 1250 μM)、E.coli (MIC: 1250 μM)、E.faecalis (MIC: 1250 μM)、S.typhimuriumand (MIC: 1250 μM) 和 S.aureus microorganisms (MIC: 1250 μM)具有抗菌活性。
T37465	CAY10742
	CAY10742 is an orally bioavailable oxadiazole antibiotic.1It is active against the Gram-positive bacteriaS. aureus,S. epidermidis,S. haemolyticus,B. cereus,B. licheniformis,E. faecalis, andE. faecium(MICs = 1-4 μg/ml), including laboratory strains and clinical isolates with varying degrees of resistance to methicillin, vancomycin, linezolid, and other antibiotics. CAY10742 (40 mg/kg) reduces the number of bacteria in mouse neutropenic thigh models of linezolid-sensitive or -resistant methicillin...
T32669	Leucomycin a5 Leukomycin A5,Turimycin H4
	Leucomycin a5 is a metabolite from the leucomycin complex, which was originally isolated from S. kitasatoensis. It is active against a variety of Gram-positive and Gram-negative bacteria (MICs = 0.04-0.8 µg/ml) but not against K. pneumoniae, S. typhimuriu
T79416	FASN-IN-6
	FASN-IN-6（Compound 44）作为脂肪酸生物合成（FAB）抑制剂表现出高效性。该化合物具备抗菌作用，针对金黄色葡萄球菌ATCC 25923及粪肠球菌ATCC 29212的最小抑菌浓度（MIC）分别为1 μg/mL与4 μg/mL。
T36746	Leoidin
	Leoidin is a depsidone originally isolated from L. gangaleoides that has antibacterial and enzyme inhibitory activities.1,2,3 It is active against the bacteria E. faecalis, H. influenzae, M. catarrhalis, S. aureus, and S. pneumoniae (MICs = 8, 32, 1, 128, and 64 μg/ml, respectively).2 Leoidin inhibits phenylalanyl-tRNA synthetase (PheRS) isolated from P. aeruginosa (IC50 = 42 μM). It also inhibits organic anion-transporting polypeptide 1B1 (OATP1B1) and OATP1B3 with Ki values of 0.08 and 1.84 μM...
T71860	Ambuic acid
	Ambuic acid is a cyclohexanone that has phytopathogenic antifungal, quorum sensing inhibitory, and antibacterial activities. Ambuic acid inhibits the biosynthesis of cyclic peptides involved in quorum sensing, including gelatinase biosynthesis-activating pheromone (GBAP) in E. faecalis, autoinducing peptide I (AIP-I) in S. aureus, and LsrD698 and LsrD826 in L. innocua. It suppresses abcess formation in a mouse model of skin infection induced by methicillin-resistant S. aureus (MRSA) when adminis...
T37887	1-Heptadecanoyl-rac-glycerol
	1-Heptadecanoyl-rac-glycerol is a monoacylglycerol that contains heptadecanoic acid at the sn-1 position. It is active against the bacteria E. aerogens, E. cloacae, P. mirabilis, and S. faecalis (MIC = 78 μg/ml for all).1 1-Heptadecanoyl-rac-glycerol has been found in T. africana, I. sonorae, and wheat bran.1,2,3 \|1. Kuete, V., Metuno, R., Ngameni, B., et al. Antimicrobial activity of the methanolic extracts and compounds from Treculia africana and Treculia acuminata (Moraceae). S. Afr. J. Bot. ...
T35607	10'-Desmethoxystreptonigrin
	10'-Desmethoxystreptonigrin is an antibiotic originally isolated from Streptomyces and a derivative of the antibiotic streptonigrin. It is active against a variety of bacteria, including S. aureus, S. faecalis, E. coli, K. pneumoniae, and P. vulgaris (MICs = 0.4, 1.6, 3.1, 3.1 and 0.4 μg/ml, respectively). 10'-Desmethoxystreptonigrin is cytotoxic to HCT116 colon and A2780 ovarian cancer cells (IC50s = 0.004 and 0.001 μg/ml, respectively), as well as HCT116 cells resistant to etoposide and tenipo...
T38009	Kocurin
	Kocurin is a thiazolyl peptide originally isolated fromK. palustrisand has antibiotic activity.1It is active against methicillin-resistantS. aureus(MRSA; MIC = 0.25 μg/ml), as well asB. subtilisandE. faeciumin a solid agar test when used at a concentration of 8 μg/ml. Kocurin is also active againstE. faecium,E. faecalis,S. epidermidis, and clinical isolates of vancomycin-resistant enterococci (MICs = 0.004-1.025 μg/ml).2In vivo, kocurin (2.5, 5, and 10 mg/ml) increases survival in a mouse model ...
T36021	Flumequine-13C3 Flumequine-13C3
	Flumequine-13C3is intended for use as an internal standard for the quantification of flumequine by GC- or LC-MS. Flumequine is a fluoroquinolone antibiotic.1It is active againstS. aureus, S. pyogenes, B. subtilis, E. coli, P. aeruginosa, S. faecalis, andK. pneumoniae(MICs = 1-100 μg/ml). Flumequine is also active against field isolates of B. hyodysenteriae (MICs = 6.25-200 μg/ml).2It inhibits DNA gyrase, disrupting supercoiling of bacterial DNA to block transcription and replication.3In vivo, fl...
T37468	Siamycin I
	Siamycin I is a tricyclic peptide originally isolated from Streptomyces and has antiviral and antibacterial activities. It is active against laboratory strains and clinical isolates of HIV-1 (ED50s = 0.05-0.45 and 0.89-5.7 μM, respectively), as well as the CBL-20 strain of HIV-2 (ED50 = 0.45 μM), in vitro. Siamycin I inhibits HIV-induced fusion of C8166 T cells with HIV-1-infected CEM-SS cells with an ED50 value of 0.08 μM. It is also active against B. subtilis, M. luteus, and S. aureus (MICs = ...

化合物

Cefuroxime sodium

Cat.No: T1224

Synonym: Anaptivan,头孢呋辛钠,Cefuroxime sodium salt,Biociclin

Target: Antibacterial, Antibiotic

Pyrrofolic acid

Cat.No: T26007

Cat.No: T38021

Cat.No: T38334

Antibacterial agent 113

Cat.No: T63252

Cat.No: T13149

Target: Antibacterial

Antiproliferative agent-33

Cat.No: T83022

Cat.No: T80371

Cat.No: T38321

Parvodicin Complex

Cat.No: T38314

Cat.No: T37254

Betulinic Aldehyde oxime

Cat.No: T37039

Cat.No: T80376

1-Undecanoyl-rac-glycerol

Cat.No: T37286

Cat.No: T38167

Cat.No: T36181

Tilapia piscidin 3

Cat.No: T80378

Antibacterial agent 112

Cat.No: T64197

Cat.No: T37465

Cat.No: T32669

Synonym: Leukomycin A5,Turimycin H4

Cat.No: T79416

Cat.No: T36746

Cat.No: T71860

1-Heptadecanoyl-rac-glycerol

Cat.No: T37887

10'-Desmethoxystreptonigrin

Cat.No: T35607

Cat.No: T38009

Flumequine-13C3

Cat.No: T36021

Synonym: Flumequine-13C3

Cat.No: T37468

Cat. No.	Product Name	Target	Signaling Pathways
T83862	Bactobolin A hydrochloride BN-183B
	Bactobolin A 是一种最初从 Pseudomonas 中分离出的微生物代谢产物，具有抗生素和抗癌活性。它对 S. aureus、S. epidermidis、S. faecalis、B. anthracis、B. subtilis、E. coli、S. typhi 和 S. dysenteriae 活跃(MICs = 0.1-12.5 µg/ml)。在体内，bactobolin A (0.25-4 mg/kg) 提高了 L1210 小鼠白血病模型的存活率。
TN3404	Altholactone	BCL; p38 MAPK; ROS; Akt; Caspase; Antifection; p53	Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of various types of cancer cells through inducing apoptosis via oxidative stress, including bladd
T35754	Aszonapyrone A
	Aszonapyrone A is a meroditerpene fungal metabolite that has been found in Neosartorya and has diverse biological activities.1,2,3 It inhibits the growth of MCF-7, NCI H460, and A375-C5 cancer cells (GI50s = 13.6, 11.6, and 10.2 μM, respectively).1 Aszonapyrone A is active against multidrug-resistant isolates of S. aureus, E. faecalis, and E. faecium (MICs = 8, 16, and 16 μg/ml, respectively) and inhibits S. aureus biofilm formation.2 It is also active against P. falciparum in vitro (IC50 = 1.34...
TN1991	Norchelerythrine	Antifection	Microbiology/Virology
	Norchelerythrine shows significant inhibitory activity against Staphylococcus aureus ATCC 6538 with MIC values ranging from 12.5 to 50 ug/mL. It exhibits strong antifeeding activity in a concentration-dependant manner with the EC50 of 62.67 ppm.

天然产物

Bactobolin A hydrochloride

Cat.No: T83862

Synonym: BN-183B

Cat.No: TN3404

Target: BCL, p38 MAPK, ROS, Akt, Caspase, Antifection, p53

Cat.No: T35754

Norchelerythrine

Cat.No: TN1991

Target: Antifection

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